The U3 company works with drive makers (parent company SanDisk as well as others) to deliver custom versions of applications designed for Microsoft Windows from a special flash drive; U3-compatible devices are designed to autoload a menu when plugged into a computer running Windows. Applications must be modified for the U3 platform not to leave any data on the host machine. U3 also provides a software framework for independent software vendors interested in their platform.
When used in the same manner as external rotating drives (hard drives, optical drives, or floppy drives), i.e. in ignorance of their technology, USB drives' failure is more likely to be sudden: while rotating drives can fail instantaneously, they more frequently give some indication (noises, slowness) that they are about to fail, often with enough advance warning that data can be removed before total failure. USB drives give little or no advance warning of failure. Furthermore, when internal wear-leveling is applied to prolong life of the flash drive, once failure of even part of the memory occurs it can be difficult or impossible to use the remainder of the drive, which differs from magnetic media, where bad sectors can be marked permanently not to be used.[74]

Particularly with the advent of USB, external hard disks have become widely available and inexpensive. External hard disk drives currently cost less per gigabyte than flash drives and are available in larger capacities. Some hard drives support alternative and faster interfaces than USB 2.0 (e.g., Thunderbolt, FireWire and eSATA). For consecutive sector writes and reads (for example, from an unfragmented file), most hard drives can provide a much higher sustained data rate than current NAND flash memory, though mechanical latencies seriously impact hard drive performance.
Some file systems are designed to distribute usage over an entire memory device without concentrating usage on any part (e.g., for a directory) to prolong the life of simple flash memory devices. Some USB flash drives have this 'wear leveling' feature built into the software controller to prolong device life, while others do not, so it is not necessarily helpful to install one of these file systems.[39]
USB flash drives are only limited by the cost of the storage space and the physical constraints of the drive. Some of the cheaper flash drives can store less than a gigabyte, but modern high-end flash drives can store as much as 1TB of data, about equivalent to a typical hard drive. A standard external USB drive can store or backup around 64GB, 128GB, 256GB, or 512GB of data. As storage space increases, USB flash drives have become proficient at storing massive files such as ultra high-definition videos that display at 4K or even 8K resolution.
As highly portable media, USB flash drives are easily lost or stolen. All USB flash drives can have their contents encrypted using third-party disk encryption software, which can often be run directly from the USB drive without installation (for example, FreeOTFE), although some, such as BitLocker, require the user to have administrative rights on every computer it is run on.

USB 2.0 flash drives have a transfer rate of up to 480Mbps, while USB 3.0 flash drives allow for transfer rates 10 times faster — up to 4.8Gbps. However, you can only take advantage of this higher speed if your device has a USB 3.0 port. Although USB 3.0 flash drives and other devices are backwards compatible with USB 2.0 ports, they will only operate at a USB 2.0 rate.
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