Lexar is attempting to introduce a USB FlashCard, which would be a compact USB flash drive intended to replace various kinds of flash memory cards. Pretec introduced a similar card, which also plugs into any USB port, but is just one quarter the thickness of the Lexar model.[85] Until 2008, SanDisk manufactured a product called SD Plus, which was a SecureDigital card with a USB connector.[86]
_{The applications of current data tape cartridges hardly overlap those of flash drives: on tape, cost per gigabyte is very low for large volumes, but the individual drives and media are expensive. Media have a very high capacity and very fast transfer speeds, but store data sequentially and are very slow for random access of data. While disk-based backup is now the primary medium of choice for most companies, tape backup is still popular for taking data off-site for worst-case scenarios and for very large volumes (more than a few hundreds of TB). See LTO tapes.}

Flash drives are often measured by the rate at which they transfer data. Transfer rates may be given in megabytes per second (MB/s), megabits per second (Mbit/s), or in optical drive multipliers such as "180X" (180 times 150 KiB/s).[19] File transfer rates vary considerably among devices. Second generation flash drives have claimed to read at up to 30 MB/s and write at about half that rate, which was about 20 times faster than the theoretical transfer rate achievable by the previous model, USB 1.1, which is limited to 12 Mbit/s (1.5 MB/s) with accounted overhead.[20] The effective transfer rate of a device is significantly affected by the data access pattern.[21]

Universal Serial Bus (USB) is a standard that defines both communication protocols and physical connections for data transfer. Using thumb drives based on this standard ensures they work with a broad range of devices, making it simple to show digital pictures on a USB-enabled television, transfer files between Apple and Microsoft computers or use your saved game on a friend's gaming console. These devices also offer plug-and-play compatibility with most operating systems and require no additional software to access the storage they provide.
The New York-based Human Rights Foundation collaborated with Forum 280 and USB Memory Direct to launch the "Flash Drives for Freedom" program.[80][81] The program was created in 2016 to smuggle flash drives with American and South Korean movies and television shows, as well as a copy of the Korean Wikipedia, into North Korea to spread pro-Western sentiment.[82][83]
^{Particularly with the advent of USB, external hard disks have become widely available and inexpensive. External hard disk drives currently cost less per gigabyte than flash drives and are available in larger capacities. Some hard drives support alternative and faster interfaces than USB 2.0 (e.g., Thunderbolt, FireWire and eSATA). For consecutive sector writes and reads (for example, from an unfragmented file), most hard drives can provide a much higher sustained data rate than current NAND flash memory, though mechanical latencies seriously impact hard drive performance.}
When used in the same manner as external rotating drives (hard drives, optical drives, or floppy drives), i.e. in ignorance of their technology, USB drives' failure is more likely to be sudden: while rotating drives can fail instantaneously, they more frequently give some indication (noises, slowness) that they are about to fail, often with enough advance warning that data can be removed before total failure. USB drives give little or no advance warning of failure. Furthermore, when internal wear-leveling is applied to prolong life of the flash drive, once failure of even part of the memory occurs it can be difficult or impossible to use the remainder of the drive, which differs from magnetic media, where bad sectors can be marked permanently not to be used.[74]
_{"Helps transfer data without bulky external drives....Compared to the Ultra Flash Drives I purchased (which are designed for faster downloads), this Flash Drive took just a little bit longer for downloading a large quantity of items, but it really was not that much of a time difference, so I am extremely satisfied with the speed and abilities of the Cruzer"}
With wide deployment(s) of flash drives being used in various environments (secured or otherwise), the issue of data and information security remains important. The use of biometrics and encryption is becoming the norm with the need for increased security for data; on-the-fly encryption systems are particularly useful in this regard, as they can transparently encrypt large amounts of data. In some cases a secure USB drive may use a hardware-based encryption mechanism that uses a hardware module instead of software for strongly encrypting data. IEEE 1667 is an attempt to create a generic authentication platform for USB drives. It is supported in Windows 7 and Windows Vista (Service Pack 2 with a hotfix).[47]

Some manufacturers deploy physical authentication tokens in the form of a flash drive. These are used to control access to a sensitive system by containing encryption keys or, more commonly, communicating with security software on the target machine. The system is designed so the target machine will not operate except when the flash drive device is plugged into it. Some of these "PC lock" devices also function as normal flash drives when plugged into other machines.

Flash memory cards, e.g., Secure Digital cards, are available in various formats and capacities, and are used by many consumer devices. However, while virtually all PCs have USB ports, allowing the use of USB flash drives, memory card readers are not commonly supplied as standard equipment (particularly with desktop computers). Although inexpensive card readers are available that read many common formats, this results in two pieces of portable equipment (card plus reader) rather than one.
Counterfeit USB flash drives are sometimes sold with claims of having higher capacities than they actually have. These are typically low capacity USB drives which are modified so that they emulate larger capacity drives (for example, a 2 GB drive being marketed as a 64 GB drive). When plugged into a computer, they report themselves as being the larger capacity they were sold as, but when data is written to them, either the write fails, the drive freezes up, or it overwrites existing data. Software tools exist to check and detect fake USB drives,[43][44] and in some cases it is possible to repair these devices to remove the false capacity information and use its real storage limit.[45]

USB 2.0 flash drives have a transfer rate of up to 480Mbps, while USB 3.0 flash drives allow for transfer rates 10 times faster — up to 4.8Gbps. However, you can only take advantage of this higher speed if your device has a USB 3.0 port. Although USB 3.0 flash drives and other devices are backwards compatible with USB 2.0 ports, they will only operate at a USB 2.0 rate.