Flash drives can be defragmented. There is a widespread opinion that defragmenting brings little advantage (as there is no mechanical head that moves from fragment to fragment), and that defragmenting shortens the life of the drive by making many unnecessary writes.[37] However, some sources claim[38] that defragmenting a flash drive can improve performance (mostly due to improved caching of the clustered data), and the additional wear on flash drives may not be significant.

The 32GB capacity of this SanDisk Ultra SDCZ48-032G-A46 flash drive provides ample room to store photos, music, videos and other files. The USB 3.0 interface and up to 80MB/sec. read speed make it easy to transfer files to and from your computer. (Ten times faster than USB 2.0 drives. Write speeds up to 10 times faster than Cruzer USB 2.0 drive.)* *USB 3.0 port required. Based on internal testing; performance may be lower depending upon host device.

Particularly with the advent of USB, external hard disks have become widely available and inexpensive. External hard disk drives currently cost less per gigabyte than flash drives and are available in larger capacities. Some hard drives support alternative and faster interfaces than USB 2.0 (e.g., Thunderbolt, FireWire and eSATA). For consecutive sector writes and reads (for example, from an unfragmented file), most hard drives can provide a much higher sustained data rate than current NAND flash memory, though mechanical latencies seriously impact hard drive performance.
Most USB flash drives do not include a write protection mechanism. This feature, which gradually became less common, consists of a switch on the housing of the drive itself, that prevents the host computer from writing or modifying data on the drive. For example, write protection makes a device suitable for repairing virus-contaminated host computers without the risk of infecting a USB flash drive itself. In contrast to SD cards, write protection on USB flash drives (when available) is connected to the drive circuitry, and is handled by the drive itself instead of the host (on SD cards handling of the write-protection notch is optional).
^{In a typical well-conducted review of a number of high-performance USB 3.0 drives, a drive that could read large files at 68 MB/s and write at 46 MB/s, could only manage 14 MB/s and 0.3 MB/s with many small files. When combining streaming reads and writes the speed of another drive, that could read at 92 MB/s and write at 70 MB/s, was 8 MB/s. These differences differ radically from one drive to another; some drives could write small files at over 10% of the speed for large ones. The examples given are chosen to illustrate extremes....′[46]}

The memory in flash drives is commonly engineered with multi-level cell (MLC) based memory that is good for around 3,000-5,000 program-erase cycles,[40] but some flash drives have single-level cell (SLC) based memory that is good for around 100,000 writes. There is virtually no limit to the number of reads from such flash memory, so a well-worn USB drive may be write-protected to help ensure the life of individual cells.

When used in the same manner as external rotating drives (hard drives, optical drives, or floppy drives), i.e. in ignorance of their technology, USB drives' failure is more likely to be sudden: while rotating drives can fail instantaneously, they more frequently give some indication (noises, slowness) that they are about to fail, often with enough advance warning that data can be removed before total failure. USB drives give little or no advance warning of failure. Furthermore, when internal wear-leveling is applied to prolong life of the flash drive, once failure of even part of the memory occurs it can be difficult or impossible to use the remainder of the drive, which differs from magnetic media, where bad sectors can be marked permanently not to be used.[74]

This drive’s small size won over our testers: “Its small profile allows it to stay plugged into a computer even when transporting it in a bag or case, which is not something most flash drives can claim,” one person said. Lifewire reviewers agree that the drive’s tiny footprint makes it much more likely to get lost, but they say its fast read speeds and convenient portability easily make up for that.
A recent development for the use of a USB Flash Drive as an application carrier is to carry the Computer Online Forensic Evidence Extractor (COFEE) application developed by Microsoft. COFEE is a set of applications designed to search for and extract digital evidence on computers confiscated from suspects.[48] Forensic software is required not to alter, in any way, the information stored on the computer being examined. Other forensic suites run from CD-ROM or DVD-ROM, but cannot store data on the media they are run from (although they can write to other attached devices, such as external drives or memory sticks).

Unlike solid-state memory, hard drives are susceptible to damage by shock (e.g., a short fall) and vibration, have limitations on use at high altitude, and although they are shielded by their casings, they are vulnerable when exposed to strong magnetic fields. In terms of overall mass, hard drives are usually larger and heavier than flash drives; however, hard disks sometimes weigh less per unit of storage. Like flash drives, hard disks also suffer from file fragmentation, which can reduce access speed.

Many types of USB drive, sometimes referred to as a thumb drive, also have handy features like a key chain ring or a small LED flashlight. Some can even transmit your data wirelessly for the ultimate in digital convenience. And as with any fun accessory, there are plenty of novelty versions of flash drives designed to show your personality, display your sense of humor, or broadcast your team loyalty.