Yes you can but if you have a lot of files, a flash drive won't back it all up. If you only need to back up 32GB-64GB for example, you could back it up on the flash drive. However, anything bigger isn't sensible for flash drives; you're better off getting an external hard drive. Also, it's not a long-term storage option––it can corrupt easily or be lost.
Most flash drives ship preformatted with the FAT32, or exFAT file systems. The ubiquity of the FAT32 file system allows the drive to be accessed on virtually any host device with USB support. Also, standard FAT maintenance utilities (e.g., ScanDisk) can be used to repair or retrieve corrupted data. However, because a flash drive appears as a USB-connected hard drive to the host system, the drive can be reformatted to any file system supported by the host operating system.
Installers of some operating systems can be stored to a flash drive instead of a CD or DVD, including various Linux distributions, Windows 7 and newer versions, and macOS. In particular, Mac OS X 10.7 is distributed only online, through the Mac App Store, or on flash drives; for a MacBook Air with Boot Camp and no external optical drive, a flash drive can be used to run installation of Windows or Linux.
Flash memory cards, e.g., Secure Digital cards, are available in various formats and capacities, and are used by many consumer devices. However, while virtually all PCs have USB ports, allowing the use of USB flash drives, memory card readers are not commonly supplied as standard equipment (particularly with desktop computers). Although inexpensive card readers are available that read many common formats, this results in two pieces of portable equipment (card plus reader) rather than one.
Particularly with the advent of USB, external hard disks have become widely available and inexpensive. External hard disk drives currently cost less per gigabyte than flash drives and are available in larger capacities. Some hard drives support alternative and faster interfaces than USB 2.0 (e.g., Thunderbolt, FireWire and eSATA). For consecutive sector writes and reads (for example, from an unfragmented file), most hard drives can provide a much higher sustained data rate than current NAND flash memory, though mechanical latencies seriously impact hard drive performance.
Floppy disk hardware emulators exist which effectively utilize the internal connections and physical attributes of a floppy disk drive to utilize a device where a USB flash drive emulates the storage space of a floppy disk in a solid state form, and can be divided into a number of individual virtual floppy disk images using individual data channels.
Features: 100% New&High Quality Storage Capacity: 32GB Support USB version 2.0 and 1.0 Easy plug and play installation Interface: USB 2.0; Due to the inner system and procedure data will occupy some space and the real capacity will reduce lightly Stylish lightweight; portable,new concept modeling,classic fashion,compact Brisk High Speed; plug and play, in line with USB 2.0 specification, data transfer speed. Compatible with Windows 7/Windows 8, Windows 10, Windows XP, Windows Vista, Mac OS 9.0,Hi-Speed USB 2.0 port required for high speed transfer Support solution for Linux kernel version 2.4 or later version Driveless for OS 9X or up Durable solid-state storage No external power is required 4.5V ~ 5.5V from USB port The data read speed: 8M-18M/S(USB2.0) The data write speed: 3M-7M/S(USB2.
"Nice device for bulky files....I have 2 of these flash drives and it's more convenient for me to store backups of my most important files on 2 of these flash drives than an external drive because it's easier for me to transfer my data files between 3 devices, carry the drive around in my pocket, and the transfers are easy and fast since it's USB 3.0"
The memory in flash drives is commonly engineered with multi-level cell (MLC) based memory that is good for around 3,000-5,000 program-erase cycles,[40] but some flash drives have single-level cell (SLC) based memory that is good for around 100,000 writes. There is virtually no limit to the number of reads from such flash memory, so a well-worn USB drive may be write-protected to help ensure the life of individual cells.
Most USB-based flash technology integrates a printed circuit board with a metal tip, which is simply soldered on. As a result, the stress point is where the two pieces join. The quality control of some manufacturers does not ensure a proper solder temperature, further weakening the stress point.[77][78] Since many flash drives stick out from computers, they are likely to be bumped repeatedly and may break at the stress point. Most of the time, a break at the stress point tears the joint from the printed circuit board and results in permanent damage. However, some manufacturers produce discreet flash drives that do not stick out, and others use a solid metal uni-body that has no easily discernible stress point. SD cards serve as a good alternative to USB drives since they can be inserted flush.
The various writable and re-writable forms of CD and DVD are portable storage media supported by the vast majority of computers as of 2008. CD-R, DVD-R, and DVD+R can be written to only once, RW varieties up to about 1,000 erase/write cycles, while modern NAND-based flash drives often last for 500,000 or more erase/write cycles. DVD-RAM discs are the most suitable optical discs for data storage involving much rewriting.
“The DataTraveler's tiny metal frame and prominent key ring make it easily portable,” our tester said of this flash drive. He added, “Downloading files off the drive itself is fast and easy, at over 100 MB/s, and it's also one of the cheapest USB 3.0 flash drives you can get.” The downside? “While read speeds were fine, the DataTraveler struggles to actually copy files onto the drive,” our reviewer explained. “Despite supporting USB 3.0, it barely tops write speeds of 10 MB/s, and lacks any other features.” The takeaway: “We'd only recommend this product as a cheap way for business professionals to pass out digital content to clients, or for networking,” he stated.
Some file systems are designed to distribute usage over an entire memory device without concentrating usage on any part (e.g., for a directory) to prolong the life of simple flash memory devices. Some USB flash drives have this 'wear leveling' feature built into the software controller to prolong device life, while others do not, so it is not necessarily helpful to install one of these file systems.[39]
Buoyed by its rocket-like speeds, the Extreme Go lives up to its name by transferring a 4K movie in less than 40 seconds — that's nearly 35 times the speed of a USB 2.0 drive and thanks to USB 3.1 hardware. Beyond its fast operation, the Sandisk looks as good as it performs with a sleek and slim package that's 2.79 x 0.84 x 0.45 inches in size and weighs only 4.8 ounces. The retractable connector makes it easy to store when not in use and it is backward compatible with any USB 3.0 or USB 2.0 port. Tucked inside its diminutive profile is a choice of 64GB or 128GB of storage capacity and it comes complete with data storage recovery in the event of an accidental file deletion. 

Specially manufactured flash drives are available that have a tough rubber or metal casing designed to be waterproof and virtually "unbreakable". These flash drives retain their memory after being submerged in water, and even through a machine wash. Leaving such a flash drive out to dry completely before allowing current to run through it has been known to result in a working drive with no future problems. Channel Five's Gadget Show cooked one of these flash drives with propane, froze it with dry ice, submerged it in various acidic liquids, ran over it with a jeep and fired it against a wall with a mortar. A company specializing in recovering lost data from computer drives managed to recover all the data on the drive.[64] All data on the other removable storage devices tested, using optical or magnetic technologies, were destroyed.
Flash drives implement the USB mass storage device class so that most modern operating systems can read and write to them without installing device drivers. The flash drives present a simple block-structured logical unit to the host operating system, hiding the individual complex implementation details of the various underlying flash memory devices. The operating system can use any file system or block addressing scheme. Some computers can boot up from flash drives.
In a typical well-conducted review of a number of high-performance USB 3.0 drives, a drive that could read large files at 68 MB/s and write at 46 MB/s, could only manage 14 MB/s and 0.3 MB/s with many small files. When combining streaming reads and writes the speed of another drive, that could read at 92 MB/s and write at 70 MB/s, was 8 MB/s. These differences differ radically from one drive to another; some drives could write small files at over 10% of the speed for large ones. The examples given are chosen to illustrate extremes....′[46]

Motherboard firmware (including BIOS and UEFI) can be updated using USB flash drives. Usually, new firmware image is downloaded and placed onto a FAT16- or FAT32-formatted USB flash drive connected to a system which is to be updated, and path to the new firmware image is selected within the update component of system's firmware.[49] Some motherboard manufacturers are also allowing such updates to be performed without the need for entering system's firmware update component, making it possible to easily recover systems with corrupted firmware.[50]

Specially manufactured flash drives are available that have a tough rubber or metal casing designed to be waterproof and virtually "unbreakable". These flash drives retain their memory after being submerged in water, and even through a machine wash. Leaving such a flash drive out to dry completely before allowing current to run through it has been known to result in a working drive with no future problems. Channel Five's Gadget Show cooked one of these flash drives with propane, froze it with dry ice, submerged it in various acidic liquids, ran over it with a jeep and fired it against a wall with a mortar. A company specializing in recovering lost data from computer drives managed to recover all the data on the drive.[64] All data on the other removable storage devices tested, using optical or magnetic technologies, were destroyed.

A recent development for the use of a USB Flash Drive as an application carrier is to carry the Computer Online Forensic Evidence Extractor (COFEE) application developed by Microsoft. COFEE is a set of applications designed to search for and extract digital evidence on computers confiscated from suspects.[48] Forensic software is required not to alter, in any way, the information stored on the computer being examined. Other forensic suites run from CD-ROM or DVD-ROM, but cannot store data on the media they are run from (although they can write to other attached devices, such as external drives or memory sticks).

Digital audio files can be transported from one computer to another like any other file, and played on a compatible media player (with caveats for DRM-locked files). In addition, many home Hi-Fi and car stereo head units are now equipped with a USB port. This allows a USB flash drive containing media files in a variety of formats to be played directly on devices which support the format. Some LCD monitors for consumer HDTV viewing have a dedicated USB port through which music and video files can also be played without use of a personal computer.
Flash drives are also cost-effective. You can securely store a few dozen gigabytes of data for less than $30, and these devices range in storage capacity, price and overall size - equal to the amount you're willing to invest. Some even have special features like lanyards, locks, belt clips and key fobs to make them easier to carry and keep track of.
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