Most flash drives ship preformatted with the FAT32, or exFAT file systems. The ubiquity of the FAT32 file system allows the drive to be accessed on virtually any host device with USB support. Also, standard FAT maintenance utilities (e.g., ScanDisk) can be used to repair or retrieve corrupted data. However, because a flash drive appears as a USB-connected hard drive to the host system, the drive can be reformatted to any file system supported by the host operating system.
A recent development for the use of a USB Flash Drive as an application carrier is to carry the Computer Online Forensic Evidence Extractor (COFEE) application developed by Microsoft. COFEE is a set of applications designed to search for and extract digital evidence on computers confiscated from suspects.[48] Forensic software is required not to alter, in any way, the information stored on the computer being examined. Other forensic suites run from CD-ROM or DVD-ROM, but cannot store data on the media they are run from (although they can write to other attached devices, such as external drives or memory sticks).
USB flash drives use the USB mass storage device class standard, supported natively by modern operating systems such as Windows, Linux, macOS and other Unix-like systems, as well as many BIOS boot ROMs. USB drives with USB 2.0 support can store more data and transfer faster than much larger optical disc drives like CD-RW or DVD-RW drives and can be read by many other systems such as the Xbox One, PlayStation 4, DVD players, automobile entertainment systems, and in a number of handheld devices such as smartphones and tablet computers, though the electronically similar SD card is better suited for those devices.
Original flash memory designs had very limited estimated lifetimes. The failure mechanism for flash memory cells is analogous to a metal fatigue mode; the device fails by refusing to write new data to specific cells that have been subject to many read-write cycles over the device's lifetime. Premature failure of a "live USB" could be circumvented by using a flash drive with a write-lock switch as a WORM device, identical to a live CD. Originally, this potential failure mode limited the use of "live USB" system to special-purpose applications or temporary tasks, such as:

To ensure this information isn't stolen as well, having a locked flash drive can keep anyone from viewing your files should the drive fall into the wrong hands. Tiny and portable, they easily slip into a pants or coat pocket, in a computer bag or purse, and come in a variety of shapes and sizes. External keypads add an additional level of security to portable memory, meaning a viewer must first input a numerical code to gain access to files. These in turn can be encrypted and password protected, deterring serious threats to personal security.
The applications of current data tape cartridges hardly overlap those of flash drives: on tape, cost per gigabyte is very low for large volumes, but the individual drives and media are expensive. Media have a very high capacity and very fast transfer speeds, but store data sequentially and are very slow for random access of data. While disk-based backup is now the primary medium of choice for most companies, tape backup is still popular for taking data off-site for worst-case scenarios and for very large volumes (more than a few hundreds of TB). See LTO tapes.

Lexar is attempting to introduce a USB FlashCard, which would be a compact USB flash drive intended to replace various kinds of flash memory cards. Pretec introduced a similar card, which also plugs into any USB port, but is just one quarter the thickness of the Lexar model.[85] Until 2008, SanDisk manufactured a product called SD Plus, which was a SecureDigital card with a USB connector.[86]
Universal Serial Bus (USB) is a standard that defines both communication protocols and physical connections for data transfer. Using thumb drives based on this standard ensures they work with a broad range of devices, making it simple to show digital pictures on a USB-enabled television, transfer files between Apple and Microsoft computers or use your saved game on a friend's gaming console. These devices also offer plug-and-play compatibility with most operating systems and require no additional software to access the storage they provide.
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