A drawback to the small size of flash drives is that they are easily misplaced or otherwise lost. This is a particular problem if they contain sensitive data (see data security). As a consequence, some manufacturers have added encryption hardware to their drives, although software encryption systems which can be used in conjunction with any mass storage medium will achieve the same result. Most drives can be attached to keychains or lanyards. The USB plug is usually retractable or fitted with a removable protective cap.
Motherboard firmware (including BIOS and UEFI) can be updated using USB flash drives. Usually, new firmware image is downloaded and placed onto a FAT16- or FAT32-formatted USB flash drive connected to a system which is to be updated, and path to the new firmware image is selected within the update component of system's firmware.[49] Some motherboard manufacturers are also allowing such updates to be performed without the need for entering system's firmware update component, making it possible to easily recover systems with corrupted firmware.[50]
Flash memory cards, e.g., Secure Digital cards, are available in various formats and capacities, and are used by many consumer devices. However, while virtually all PCs have USB ports, allowing the use of USB flash drives, memory card readers are not commonly supplied as standard equipment (particularly with desktop computers). Although inexpensive card readers are available that read many common formats, this results in two pieces of portable equipment (card plus reader) rather than one.

Some manufacturers, aiming at a "best of both worlds" solution, have produced card readers that approach the size and form of USB flash drives (e.g., Kingston MobileLite,[65] SanDisk MobileMate[66]) These readers are limited to a specific subset of memory card formats (such as SD, microSD, or Memory Stick), and often completely enclose the card, offering durability and portability approaching, if not quite equal to, that of a flash drive. Although the combined cost of a mini-reader and a memory card is usually slightly higher than a USB flash drive of comparable capacity, the reader + card solution offers additional flexibility of use, and virtually "unlimited" capacity. The ubiquity of SD cards is such that, circa 2011, due to economies of scale, their price is now less than an equivalent-capacity USB flash drive, even with the added cost of a USB SD card reader.

Most USB-based flash technology integrates a printed circuit board with a metal tip, which is simply soldered on. As a result, the stress point is where the two pieces join. The quality control of some manufacturers does not ensure a proper solder temperature, further weakening the stress point.[77][78] Since many flash drives stick out from computers, they are likely to be bumped repeatedly and may break at the stress point. Most of the time, a break at the stress point tears the joint from the printed circuit board and results in permanent damage. However, some manufacturers produce discreet flash drives that do not stick out, and others use a solid metal uni-body that has no easily discernible stress point. SD cards serve as a good alternative to USB drives since they can be inserted flush.
Many types of USB drive, sometimes referred to as a thumb drive, also have handy features like a key chain ring or a small LED flashlight. Some can even transmit your data wirelessly for the ultimate in digital convenience. And as with any fun accessory, there are plenty of novelty versions of flash drives designed to show your personality, display your sense of humor, or broadcast your team loyalty.
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