Yes you can but if you have a lot of files, a flash drive won't back it all up. If you only need to back up 32GB-64GB for example, you could back it up on the flash drive. However, anything bigger isn't sensible for flash drives; you're better off getting an external hard drive. Also, it's not a long-term storage option––it can corrupt easily or be lost.
It's never been easier to take all the files, data or media you want with you wherever you go. Generally about the size of a stick of gum, a USB flash drive lets you store any file from your computer so you can save it, transport it, and load it onto another computer in seconds. You simply plug the flash drive into your USB port and drag any files you want onto its icon on your desktop. Best of all, flash drives have no internal moving parts, so they're very resistant to breaking by being bumped or dropped.