Floppy disk drives are rarely fitted to modern computers and are obsolete for normal purposes, although internal and external drives can be fitted if required. Floppy disks may be the method of choice for transferring data to and from very old computers without USB or booting from floppy disks, and so they are sometimes used to change the firmware on, for example, BIOS chips. Devices with removable storage like older Yamaha music keyboards are also dependent on floppy disks, which require computers to process them. Newer devices are built with USB flash drive support.
To ensure this information isn't stolen as well, having a locked flash drive can keep anyone from viewing your files should the drive fall into the wrong hands. Tiny and portable, they easily slip into a pants or coat pocket, in a computer bag or purse, and come in a variety of shapes and sizes. External keypads add an additional level of security to portable memory, meaning a viewer must first input a numerical code to gain access to files. These in turn can be encrypted and password protected, deterring serious threats to personal security.
Flash drives may present a significant security challenge for some organizations. Their small size and ease of use allows unsupervised visitors or employees to store and smuggle out confidential data with little chance of detection. Both corporate and public computers are vulnerable to attackers connecting a flash drive to a free USB port and using malicious software such as keyboard loggers or packet sniffers.

Some manufacturers deploy physical authentication tokens in the form of a flash drive. These are used to control access to a sensitive system by containing encryption keys or, more commonly, communicating with security software on the target machine. The system is designed so the target machine will not operate except when the flash drive device is plugged into it. Some of these "PC lock" devices also function as normal flash drives when plugged into other machines.

Lexar is attempting to introduce a USB FlashCard, which would be a compact USB flash drive intended to replace various kinds of flash memory cards. Pretec introduced a similar card, which also plugs into any USB port, but is just one quarter the thickness of the Lexar model.[85] Until 2008, SanDisk manufactured a product called SD Plus, which was a SecureDigital card with a USB connector.[86]

There's a lot to choose from when it comes to buying a flash drive. The most important thing to consider is size. The whole point of a USB drive is to store lots of data in a small space, so think about what kinds of files you'll want to house on your flash drive. Movies and music take quite a bit of space, so if you're carrying your whole entertainment library with you, you'll want a big thumb drive – at least 16GB. Books and other text-based documents require relatively little storage space, so people like students and working professionals using Microsoft Office would be happy transferring Word documents or Excel files with as little as 1GB of space. On the other hand, if you are using photo or music editing software, you'll want a USB flash drive with lots of storage capacity to transfer graphic and music files.