Unlike solid-state memory, hard drives are susceptible to damage by shock (e.g., a short fall) and vibration, have limitations on use at high altitude, and although they are shielded by their casings, they are vulnerable when exposed to strong magnetic fields. In terms of overall mass, hard drives are usually larger and heavier than flash drives; however, hard disks sometimes weigh less per unit of storage. Like flash drives, hard disks also suffer from file fragmentation, which can reduce access speed.
Yes you can but if you have a lot of files, a flash drive won't back it all up. If you only need to back up 32GB-64GB for example, you could back it up on the flash drive. However, anything bigger isn't sensible for flash drives; you're better off getting an external hard drive. Also, it's not a long-term storage option––it can corrupt easily or be lost.
There's a lot to choose from when it comes to buying a flash drive. The most important thing to consider is size. The whole point of a USB drive is to store lots of data in a small space, so think about what kinds of files you'll want to house on your flash drive. Movies and music take quite a bit of space, so if you're carrying your whole entertainment library with you, you'll want a big thumb drive – at least 16GB. Books and other text-based documents require relatively little storage space, so people like students and working professionals using Microsoft Office would be happy transferring Word documents or Excel files with as little as 1GB of space. On the other hand, if you are using photo or music editing software, you'll want a USB flash drive with lots of storage capacity to transfer graphic and music files.