For computers set up to be bootable from a USB drive, it is possible to use a flash drive containing a bootable portable operating system to access the files of the computer, even if the computer is password protected. The password can then be changed, or it may be possible to crack the password with a password cracking program and gain full control over the computer. Encrypting files provides considerable protection against this type of attack.
Some manufacturers deploy physical authentication tokens in the form of a flash drive. These are used to control access to a sensitive system by containing encryption keys or, more commonly, communicating with security software on the target machine. The system is designed so the target machine will not operate except when the flash drive device is plugged into it. Some of these "PC lock" devices also function as normal flash drives when plugged into other machines.
Most flash drives ship preformatted with the FAT32, or exFAT file systems. The ubiquity of the FAT32 file system allows the drive to be accessed on virtually any host device with USB support. Also, standard FAT maintenance utilities (e.g., ScanDisk) can be used to repair or retrieve corrupted data. However, because a flash drive appears as a USB-connected hard drive to the host system, the drive can be reformatted to any file system supported by the host operating system.

When used in the same manner as external rotating drives (hard drives, optical drives, or floppy drives), i.e. in ignorance of their technology, USB drives' failure is more likely to be sudden: while rotating drives can fail instantaneously, they more frequently give some indication (noises, slowness) that they are about to fail, often with enough advance warning that data can be removed before total failure. USB drives give little or no advance warning of failure. Furthermore, when internal wear-leveling is applied to prolong life of the flash drive, once failure of even part of the memory occurs it can be difficult or impossible to use the remainder of the drive, which differs from magnetic media, where bad sectors can be marked permanently not to be used.[74]
The various writable and re-writable forms of CD and DVD are portable storage media supported by the vast majority of computers as of 2008. CD-R, DVD-R, and DVD+R can be written to only once, RW varieties up to about 1,000 erase/write cycles, while modern NAND-based flash drives often last for 500,000 or more erase/write cycles. DVD-RAM discs are the most suitable optical discs for data storage involving much rewriting.
Unlike solid-state memory, hard drives are susceptible to damage by shock (e.g., a short fall) and vibration, have limitations on use at high altitude, and although they are shielded by their casings, they are vulnerable when exposed to strong magnetic fields. In terms of overall mass, hard drives are usually larger and heavier than flash drives; however, hard disks sometimes weigh less per unit of storage. Like flash drives, hard disks also suffer from file fragmentation, which can reduce access speed.
USB flash drives are portable and easy-to-use data storage devices. They're compatible with desktop computers and laptop computers as well as a broad range of game consoles and media devices. Use them to transfer data between systems, share files with friends and colleagues or create backups of critical information. Staples offers a complete selection of high-capacity thumb drives, including popular brands such as Lexar, PNY, Samsung, SanDisk and Verbatim.
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