Flash drives implement the USB mass storage device class so that most modern operating systems can read and write to them without installing device drivers. The flash drives present a simple block-structured logical unit to the host operating system, hiding the individual complex implementation details of the various underlying flash memory devices. The operating system can use any file system or block addressing scheme. Some computers can boot up from flash drives.

Counterfeit USB flash drives are sometimes sold with claims of having higher capacities than they actually have. These are typically low capacity USB drives which are modified so that they emulate larger capacity drives (for example, a 2 GB drive being marketed as a 64 GB drive). When plugged into a computer, they report themselves as being the larger capacity they were sold as, but when data is written to them, either the write fails, the drive freezes up, or it overwrites existing data. Software tools exist to check and detect fake USB drives,[43][44] and in some cases it is possible to repair these devices to remove the false capacity information and use its real storage limit.[45]
In a typical well-conducted review of a number of high-performance USB 3.0 drives, a drive that could read large files at 68 MB/s and write at 46 MB/s, could only manage 14 MB/s and 0.3 MB/s with many small files. When combining streaming reads and writes the speed of another drive, that could read at 92 MB/s and write at 70 MB/s, was 8 MB/s. These differences differ radically from one drive to another; some drives could write small files at over 10% of the speed for large ones. The examples given are chosen to illustrate extremes....′[46]
Original flash memory designs had very limited estimated lifetimes. The failure mechanism for flash memory cells is analogous to a metal fatigue mode; the device fails by refusing to write new data to specific cells that have been subject to many read-write cycles over the device's lifetime. Premature failure of a "live USB" could be circumvented by using a flash drive with a write-lock switch as a WORM device, identical to a live CD. Originally, this potential failure mode limited the use of "live USB" system to special-purpose applications or temporary tasks, such as:

As of 2011, newer flash memory designs have much higher estimated lifetimes. Several manufacturers are now offering warranties of 5 years or more. Such warranties should make the device more attractive for more applications. By reducing the probability of the device's premature failure, flash memory devices can now be considered for use where a magnetic disk would normally have been required. Flash drives have also experienced an exponential growth in their storage capacity over time (following the Moore's Law growth curve). As of 2013, single-packaged devices with capacities of 1 TB are readily available,[54] and devices with 16 GB capacity are very economical. Storage capacities in this range have traditionally been considered to offer adequate space, because they allow enough space for both the operating system software and some free space for the user's data.

Capacity - More so than any other feature, capacity will drive the price of a flash drive up the most. So before you make a purchase, consider how much you’re willing to spend on a flash drive and weigh that against how much capacity you’ll likely need. A flash drive with 16GB can cost you as little as $10, while a 128GB one will run up to $60 or more.

USB flash drives are often used for storage, data back-up and transfer of computer files. Compared with floppy disks or CDs, they are smaller, faster, have significantly more capacity, and are more durable due to a lack of moving parts. Additionally, they are immune to electromagnetic interference (unlike floppy disks), and are unharmed by surface scratches (unlike CDs). Until about 2005, most desktop and laptop computers were supplied with floppy disk drives in addition to USB ports, but floppy disk drives became obsolete after widespread adoption of USB ports and the larger USB drive capacity compared to the 1.44 MB 3.5-inch floppy disk.
Most USB flash drives weigh less than 30 g (1 oz).[31] While some manufacturers are competing for the smallest size[32] with the biggest memory,[33] some manufacturers differentiate their products by using elaborate housings, which are often bulky and make the drive difficult to connect to the USB port. Because the USB port connectors on a computer housing are often closely spaced, plugging a flash drive into a USB port may block an adjacent port. Such devices may carry the USB logo only if sold with a separate extension cable. Such cables are USB-compatible but do not conform to the USB standard.[34][35]
Some manufacturers deploy physical authentication tokens in the form of a flash drive. These are used to control access to a sensitive system by containing encryption keys or, more commonly, communicating with security software on the target machine. The system is designed so the target machine will not operate except when the flash drive device is plugged into it. Some of these "PC lock" devices also function as normal flash drives when plugged into other machines.
Digital audio files can be transported from one computer to another like any other file, and played on a compatible media player (with caveats for DRM-locked files). In addition, many home Hi-Fi and car stereo head units are now equipped with a USB port. This allows a USB flash drive containing media files in a variety of formats to be played directly on devices which support the format. Some LCD monitors for consumer HDTV viewing have a dedicated USB port through which music and video files can also be played without use of a personal computer.
^{Universal Disk Format (UDF) version 1.50 and above has facilities to support rewritable discs like sparing tables and virtual allocation tables, spreading usage over the entire surface of a disc and maximising life, but many older operating systems do not support this format. Packet-writing utilities such as DirectCD and InCD are available but produce discs that are not universally readable (although based on the UDF standard). The Mount Rainier standard addresses this shortcoming in CD-RW media by running the older file systems on top of it and performing defect management for those standards, but it requires support from both the CD/DVD burner and the operating system. Many drives made today do not support Mount Rainier, and many older operating systems such as Windows XP and below, and Linux kernels older than 2.6.2, do not support it (later versions do). Essentially CDs/DVDs are a good way to record a great deal of information cheaply and have the advantage of being readable by most standalone players, but they are poor at making ongoing small changes to a large collection of information. Flash drives' ability to do this is their major advantage over optical media.}
“The DataTraveler's tiny metal frame and prominent key ring make it easily portable,” our tester said of this flash drive. He added, “Downloading files off the drive itself is fast and easy, at over 100 MB/s, and it's also one of the cheapest USB 3.0 flash drives you can get.” The downside? “While read speeds were fine, the DataTraveler struggles to actually copy files onto the drive,” our reviewer explained. “Despite supporting USB 3.0, it barely tops write speeds of 10 MB/s, and lacks any other features.” The takeaway: “We'd only recommend this product as a cheap way for business professionals to pass out digital content to clients, or for networking,” he stated.
Universal Serial Bus (USB) is a standard that defines both communication protocols and physical connections for data transfer. Using thumb drives based on this standard ensures they work with a broad range of devices, making it simple to show digital pictures on a USB-enabled television, transfer files between Apple and Microsoft computers or use your saved game on a friend's gaming console. These devices also offer plug-and-play compatibility with most operating systems and require no additional software to access the storage they provide.