Yes you can but if you have a lot of files, a flash drive won't back it all up. If you only need to back up 32GB-64GB for example, you could back it up on the flash drive. However, anything bigger isn't sensible for flash drives; you're better off getting an external hard drive. Also, it's not a long-term storage option––it can corrupt easily or be lost.

Usually, such drives will be custom-stamped with a company's logo, as a form of advertising. The drive may be blank, or preloaded with graphics, documentation, web links, Flash animation or other multimedia, and free or demonstration software. Some preloaded drives are read-only, while others are configured with both read-only and user-writable segments. Such dual-partition drives are more expensive.[61]

Audio tape cassettes and high-capacity floppy disks (e.g., Imation SuperDisk), and other forms of drives with removable magnetic media, such as the Iomega Zip and Jaz drives, are now largely obsolete and rarely used. There are products in today's market that will emulate these legacy drives for both tape and disk (SCSI1/SCSI2, SASI, Magneto optic, Ricoh ZIP, Jaz, IBM3590/ Fujitsu 3490E and Bernoulli for example) in state-of-the-art Compact Flash storage devices – CF2SCSI.
A recent development for the use of a USB Flash Drive as an application carrier is to carry the Computer Online Forensic Evidence Extractor (COFEE) application developed by Microsoft. COFEE is a set of applications designed to search for and extract digital evidence on computers confiscated from suspects.[48] Forensic software is required not to alter, in any way, the information stored on the computer being examined. Other forensic suites run from CD-ROM or DVD-ROM, but cannot store data on the media they are run from (although they can write to other attached devices, such as external drives or memory sticks).
This USB 3.0 drive offers what the company is calling business-grade security with 256-bit AES hardware-based encryption. You can also choose a stepped up “managed” version that offers a more complete set of management tools using SafeConsole as support. Finally, there’s an anti-virus version that loads in ESET antivirus software out of the box to avoid trojan horses and other hacker tracking programs. All of the models are TAA-compliant, so this drive won’t be in breach of government regulations, and that USB 3.0 means that you’ll have nearly the fastest transfer speeds possible. You can pick it up in sizes ranging from 4GB to 64GB.
^{Flash drives may present a significant security challenge for some organizations. Their small size and ease of use allows unsupervised visitors or employees to store and smuggle out confidential data with little chance of detection. Both corporate and public computers are vulnerable to attackers connecting a flash drive to a free USB port and using malicious software such as keyboard loggers or packet sniffers.}
USB Memory Direct® specializes in producing customized usb flash drives for marketing and promotions and has been a leader in the industry for over fourteen years. Whether you are looking for unique custom shaped flash drives or our best selling custom printed usb drives, you will find our customer service, product quality and pricing are second to none.
Also, HP has introduced a USB floppy drive key, which is an ordinary USB flash drive with additional possilibility for performing floppy drive emulation, allowing its usage for updating system firmware where direct usage of USB flash drives is not supported. Desired mode of operation (either regular USB mass storage device or of floppy drive emulation) is made selectable by a sliding switch on the device's housing.[51][52]
Features: 100% New&High Quality Storage Capacity: 32GB Support USB version 3.0 and 3.1 Easy plug and play installation Interface: USB 3.0; Capacity: 32GB Due to the inner system and procedure data will occupy some space and the real capacity will reduce lightly Stylish lightweight; portable,new concept modeling,classic fashion,compact Brisk High Speed; plug and play, in line with USB 3.0 specification, data transfer speed. Compatible with Windows 7/Windows 8, Windows XP, Windows Vista, Hi-Speed USB 3.0 port required for high speed transfer Support solution for Linux kernel version 2.4 or later version Driveless for OS 9X or up Durable solid-state storage No external power is required 4.5V ~ 5.5V from USB port The data read speed: 20MB-30MB/S（USB 3.0） The data write speed: 10MB-15MB/S（USB.
The advent of USB 3.0 makes data transfers over ten times faster than USB 2.0. If you have USB 3.0 port on your device, and you transfer files on a regular basis, the added speed on the PNY flash drive can be a big boost for getting things done (Even if you have a USB 2.0 port, you can still use USB 3.0, but you won’t get the same speeds). Pros: Fastest file transfers of any of the options. Cons: Some found the built-in external cover difficult to move.   Image Courtesy of Amazon
It's never been easier to take all the files, data or media you want with you wherever you go. Generally about the size of a stick of gum, a USB flash drive lets you store any file from your computer so you can save it, transport it, and load it onto another computer in seconds. You simply plug the flash drive into your USB port and drag any files you want onto its icon on your desktop. Best of all, flash drives have no internal moving parts, so they're very resistant to breaking by being bumped or dropped.