A drawback to the small size of flash drives is that they are easily misplaced or otherwise lost. This is a particular problem if they contain sensitive data (see data security). As a consequence, some manufacturers have added encryption hardware to their drives, although software encryption systems which can be used in conjunction with any mass storage medium will achieve the same result. Most drives can be attached to keychains or lanyards. The USB plug is usually retractable or fitted with a removable protective cap.
Some file systems are designed to distribute usage over an entire memory device without concentrating usage on any part (e.g., for a directory) to prolong the life of simple flash memory devices. Some USB flash drives have this 'wear leveling' feature built into the software controller to prolong device life, while others do not, so it is not necessarily helpful to install one of these file systems.[39]

When used in the same manner as external rotating drives (hard drives, optical drives, or floppy drives), i.e. in ignorance of their technology, USB drives' failure is more likely to be sudden: while rotating drives can fail instantaneously, they more frequently give some indication (noises, slowness) that they are about to fail, often with enough advance warning that data can be removed before total failure. USB drives give little or no advance warning of failure. Furthermore, when internal wear-leveling is applied to prolong life of the flash drive, once failure of even part of the memory occurs it can be difficult or impossible to use the remainder of the drive, which differs from magnetic media, where bad sectors can be marked permanently not to be used.[74]

Floppy disk hardware emulators exist which effectively utilize the internal connections and physical attributes of a floppy disk drive to utilize a device where a USB flash drive emulates the storage space of a floppy disk in a solid state form, and can be divided into a number of individual virtual floppy disk images using individual data channels.
Original flash memory designs had very limited estimated lifetimes. The failure mechanism for flash memory cells is analogous to a metal fatigue mode; the device fails by refusing to write new data to specific cells that have been subject to many read-write cycles over the device's lifetime. Premature failure of a "live USB" could be circumvented by using a flash drive with a write-lock switch as a WORM device, identical to a live CD. Originally, this potential failure mode limited the use of "live USB" system to special-purpose applications or temporary tasks, such as:
The U3 company works with drive makers (parent company SanDisk as well as others) to deliver custom versions of applications designed for Microsoft Windows from a special flash drive; U3-compatible devices are designed to autoload a menu when plugged into a computer running Windows. Applications must be modified for the U3 platform not to leave any data on the host machine. U3 also provides a software framework for independent software vendors interested in their platform.
Features: 100% New&High Quality Storage Capacity: 32GB Support USB version 3.0 and 3.1 Easy plug and play installation Interface: USB 3.0; Capacity: 32GB Due to the inner system and procedure data will occupy some space and the real capacity will reduce lightly Stylish lightweight; portable,new concept modeling,classic fashion,compact Brisk High Speed; plug and play, in line with USB 3.0 specification, data transfer speed. Compatible with Windows 7/Windows 8, Windows XP, Windows Vista, Hi-Speed USB 3.0 port required for high speed transfer Support solution for Linux kernel version 2.4 or later version Driveless for OS 9X or up Durable solid-state storage No external power is required 4.5V ~ 5.5V from USB port The data read speed: 20MB-30MB/S(USB 3.0) The data write speed: 10MB-15MB/S(USB.

Features: 100% New&High Quality Storage Capacity: 32GB Support USB version 2.0 and 1.0 Easy plug and play installation Interface: USB 2.0; Due to the inner system and procedure data will occupy some space and the real capacity will reduce lightly Stylish lightweight; portable,new concept modeling,classic fashion,compact Brisk High Speed; plug and play, in line with USB 2.0 specification, data transfer speed. Compatible with Windows 7/Windows 8, Windows 10, Windows XP, Windows Vista, Mac OS 9.0,Hi-Speed USB 2.0 port required for high speed transfer Support solution for Linux kernel version 2.4 or later version Driveless for OS 9X or up Durable solid-state storage No external power is required 4.5V ~ 5.5V from USB port The data read speed: 8M-18M/S(USB2.0) The data write speed: 3M-7M/S(USB2.


Features: 100% New&High Quality Storage Capacity: 32GB Support USB version 3.0 and 3.1 Easy plug and play installation Interface: USB 3.0; Capacity: 32GB Due to the inner system and procedure data will occupy some space and the real capacity will reduce lightly Stylish lightweight; portable,new concept modeling,classic fashion,compact Brisk High Speed; plug and play, in line with USB 3.0 specification, data transfer speed. Compatible with Windows 7/Windows 8, Windows XP, Windows Vista, Hi-Speed USB 3.0 port required for high speed transfer Support solution for Linux kernel version 2.4 or later version Driveless for OS 9X or up Durable solid-state storage No external power is required 4.5V ~ 5.5V from USB port The data read speed: 20MB-30MB/S(USB 3.0) The data write speed: 10MB-15MB/S(USB.
The applications of current data tape cartridges hardly overlap those of flash drives: on tape, cost per gigabyte is very low for large volumes, but the individual drives and media are expensive. Media have a very high capacity and very fast transfer speeds, but store data sequentially and are very slow for random access of data. While disk-based backup is now the primary medium of choice for most companies, tape backup is still popular for taking data off-site for worst-case scenarios and for very large volumes (more than a few hundreds of TB). See LTO tapes.

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