Installers of some operating systems can be stored to a flash drive instead of a CD or DVD, including various Linux distributions, Windows 7 and newer versions, and macOS. In particular, Mac OS X 10.7 is distributed only online, through the Mac App Store, or on flash drives; for a MacBook Air with Boot Camp and no external optical drive, a flash drive can be used to run installation of Windows or Linux.
_{Original flash memory designs had very limited estimated lifetimes. The failure mechanism for flash memory cells is analogous to a metal fatigue mode; the device fails by refusing to write new data to specific cells that have been subject to many read-write cycles over the device's lifetime. Premature failure of a "live USB" could be circumvented by using a flash drive with a write-lock switch as a WORM device, identical to a live CD. Originally, this potential failure mode limited the use of "live USB" system to special-purpose applications or temporary tasks, such as:}
Flash memory cards, e.g., Secure Digital cards, are available in various formats and capacities, and are used by many consumer devices. However, while virtually all PCs have USB ports, allowing the use of USB flash drives, memory card readers are not commonly supplied as standard equipment (particularly with desktop computers). Although inexpensive card readers are available that read many common formats, this results in two pieces of portable equipment (card plus reader) rather than one.
Its a "branded" flash drive, so all our flash drives have imprint areas or laser etching that will make your logo pop! Whatever your event or program, there is likely a style of USB flash drive with an imprint area that provides just the right surface to make our images stand out. From 1 - 4 color spot to full-color process (try this on the credit card style drives!) your imprint will look fantastic.
^{Português: Transferir Dados de um Pen Drive para um Computador, Italiano: Trasferire i Dati da una Chiavetta USB a un Computer, Español: transferir datos de una unidad flash a una computadora, Русский: перенести данные с флешки на компьютер, Français: transférer des données d'une clé USB sur un ordinateur, Deutsch: Daten von einem USB Stick auf einen Computer übertragen, Bahasa Indonesia: Mentransfer Data dari Kandar USB ke Komputer, Nederlands: Gegevens overzetten van een USB drive naar een computer, العربية: نقل البيانات من وحدة التخزين الخارجية إلى الحاسوب, Tiếng Việt: Chuyển dữ liệu từ USB vào máy tính, ไทย: ย้ายข้อมูลจากแฟลชไดรฟ์ลงคอมพิวเตอร์}
In January 2013, tech company Kingston, released a flash drive with 1 TB of storage.[24] The first USB 3.1 type-C flash drives, with read/write speeds of around 530 MB/s, were announced in March 2015.[25] As of July 2016, flash drives within the 8 to 256 GB were sold more frequently than those between 512 GB and 1 TB units.[2][3] In 2017, Kingston Technology announced the release of a 2-TB flash drive.[26]
Some file systems are designed to distribute usage over an entire memory device without concentrating usage on any part (e.g., for a directory) to prolong the life of simple flash memory devices. Some USB flash drives have this 'wear leveling' feature built into the software controller to prolong device life, while others do not, so it is not necessarily helpful to install one of these file systems.[39]
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A recent development for the use of a USB Flash Drive as an application carrier is to carry the Computer Online Forensic Evidence Extractor (COFEE) application developed by Microsoft. COFEE is a set of applications designed to search for and extract digital evidence on computers confiscated from suspects.[48] Forensic software is required not to alter, in any way, the information stored on the computer being examined. Other forensic suites run from CD-ROM or DVD-ROM, but cannot store data on the media they are run from (although they can write to other attached devices, such as external drives or memory sticks).

Digital audio files can be transported from one computer to another like any other file, and played on a compatible media player (with caveats for DRM-locked files). In addition, many home Hi-Fi and car stereo head units are now equipped with a USB port. This allows a USB flash drive containing media files in a variety of formats to be played directly on devices which support the format. Some LCD monitors for consumer HDTV viewing have a dedicated USB port through which music and video files can also be played without use of a personal computer.

^{Many types of USB drive, sometimes referred to as a thumb drive, also have handy features like a key chain ring or a small LED flashlight. Some can even transmit your data wirelessly for the ultimate in digital convenience. And as with any fun accessory, there are plenty of novelty versions of flash drives designed to show your personality, display your sense of humor, or broadcast your team loyalty.}