Yes you can but if you have a lot of files, a flash drive won't back it all up. If you only need to back up 32GB-64GB for example, you could back it up on the flash drive. However, anything bigger isn't sensible for flash drives; you're better off getting an external hard drive. Also, it's not a long-term storage option––it can corrupt easily or be lost.
The memory in flash drives is commonly engineered with multi-level cell (MLC) based memory that is good for around 3,000-5,000 program-erase cycles,[40] but some flash drives have single-level cell (SLC) based memory that is good for around 100,000 writes. There is virtually no limit to the number of reads from such flash memory, so a well-worn USB drive may be write-protected to help ensure the life of individual cells.
Particularly with the advent of USB, external hard disks have become widely available and inexpensive. External hard disk drives currently cost less per gigabyte than flash drives and are available in larger capacities. Some hard drives support alternative and faster interfaces than USB 2.0 (e.g., Thunderbolt, FireWire and eSATA). For consecutive sector writes and reads (for example, from an unfragmented file), most hard drives can provide a much higher sustained data rate than current NAND flash memory, though mechanical latencies seriously impact hard drive performance.
Floppy disk hardware emulators exist which effectively utilize the internal connections and physical attributes of a floppy disk drive to utilize a device where a USB flash drive emulates the storage space of a floppy disk in a solid state form, and can be divided into a number of individual virtual floppy disk images using individual data channels.
Flash drives are often measured by the rate at which they transfer data. Transfer rates may be given in megabytes per second (MB/s), megabits per second (Mbit/s), or in optical drive multipliers such as "180X" (180 times 150 KiB/s).[19] File transfer rates vary considerably among devices. Second generation flash drives have claimed to read at up to 30 MB/s and write at about half that rate, which was about 20 times faster than the theoretical transfer rate achievable by the previous model, USB 1.1, which is limited to 12 Mbit/s (1.5 MB/s) with accounted overhead.[20] The effective transfer rate of a device is significantly affected by the data access pattern.[21]
A recent development for the use of a USB Flash Drive as an application carrier is to carry the Computer Online Forensic Evidence Extractor (COFEE) application developed by Microsoft. COFEE is a set of applications designed to search for and extract digital evidence on computers confiscated from suspects.[48] Forensic software is required not to alter, in any way, the information stored on the computer being examined. Other forensic suites run from CD-ROM or DVD-ROM, but cannot store data on the media they are run from (although they can write to other attached devices, such as external drives or memory sticks).
^{Installers of some operating systems can be stored to a flash drive instead of a CD or DVD, including various Linux distributions, Windows 7 and newer versions, and macOS. In particular, Mac OS X 10.7 is distributed only online, through the Mac App Store, or on flash drives; for a MacBook Air with Boot Camp and no external optical drive, a flash drive can be used to run installation of Windows or Linux.}

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Lexar is attempting to introduce a USB FlashCard, which would be a compact USB flash drive intended to replace various kinds of flash memory cards. Pretec introduced a similar card, which also plugs into any USB port, but is just one quarter the thickness of the Lexar model.[85] Until 2008, SanDisk manufactured a product called SD Plus, which was a SecureDigital card with a USB connector.[86]

^{These products use flash memory chips, a stable, high-density storage medium, to hold your data. They pack a huge amount of information into a compact form factor. Most thumb drives are less than 2 inches long and easily fit in a pocket, laptop bag or purse. Models with built-in covers protect physical connectors from damage, and select products feature rugged silicon and metal shells that enhance heat and water resistance.}